Inflammatory Myopathy with Cardiac Involvement Associated with Anti-Mitochondrial Antibodies

Chedia, Laouani Kechrid and Badreddine, Sriha and Nihed, Abdessayed and Amel, Rezgui and Monia, Karmani and Anis, Mzabi and Jihed, Anoun and Fatma, Ben Fredj and Imen, Ben Hassine and Wafa, Baya (2021) Inflammatory Myopathy with Cardiac Involvement Associated with Anti-Mitochondrial Antibodies. Journal of Advances in Medicine and Medical Research, 33 (5). pp. 50-55. ISSN 2456-8899

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Aim: Anti-mitochondrial antibodies (AMA) positive myositis is an atypical and rare form with various characteristics. We aim to highlight these specificities through this case report.

Presentation of the Case: We present the case of a young woman diagnosed with frequent polymorphic ventricular extrasystoles and left ventricular dysfunction. Two years after, she developed asthenia and muscle weakness. Clinical and biological tests confirmed the diagnosis of myositis complicated by focal myocarditis. The immunological screening revealed negative antinuclear antibodies and positive AMA type anti-AMA-M2 and anti-M2-3E. A good clinical evolution was noted under corticosteroids and methotrexate.

Discussion: Cases of primary biliary cholangitis (PBC) or positive AMA associated with other autoimmune diseases such as systemic scleroderma, Sjögren syndrome, rheumatoid arthritis and myositis have been reported. AMA’s pathogenic role on the musculoskeletal and cardiac systems remains to be clarified.

Conclusion: Inflammatory myopathy associated with AMA is a rare and serious entity, characterized by a delayed diagnosis and frequent cardiac involvement, often indicating a heavy treatment.

Item Type: Article
Uncontrolled Keywords: Myositis; arrhythmias; myocarditis; antibodies
Subjects: Science Repository > Medical Science
Depositing User: Managing Editor
Date Deposited: 10 Nov 2022 05:18
Last Modified: 26 Aug 2023 07:54

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