Chemical Constituents from Wood of Zanthoxylum rigidum Hum. and Bonpl. Ex Willd (Rutaceae) and Antileishmanial Activities

Silva, Virgínia C. Paulino and Jacinto, Marco J. and Ribeiro, Tereza A. N. and Jr., Paulo T. de Sousa and Sousa, Mayara C. and Santos, Carlos H. C. dos (2021) Chemical Constituents from Wood of Zanthoxylum rigidum Hum. and Bonpl. Ex Willd (Rutaceae) and Antileishmanial Activities. European Journal of Medicinal Plants, 32 (5). pp. 14-20. ISSN 2231-0894

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Official URL: https://doi.org/10.9734/ejmp/2021/v32i530390

Abstract

In this study was reported the structural elucidation by means of nuclear magnetic resonance (1D and 2D), FT-IR and mass spectrometry of lupeol (1), a mixture of the steroids campesterol (2), b-sitosterol (3) and stigmasterol (4), sesamin (5), trans-dimethylmatairesinol (6), trans-methylpluviatolide (7), quercetin (8), and d-mannitol (9) isolated from wood of Zanthoxylum rigidum. The lignans 5, 6 and 7 were tested for their ability to inhibit the proliferation of the promastigote forms of Leishmania braziliensis and Leishmania chagasi. Only sesamin (5) and trans-methylpluviatolide (7) showed moderate inhibitory activity with IC50 = 22.4 and 33.6, SI = 3.87 and 2.41 and CC50 = 86.9 and 81.2, for L. braziliensis and L. chagasi, respectively, compared to the positive control (amphotericin B).

Item Type:	Article
Subjects:	Science Repository > Medical Science
Depositing User:	Managing Editor
Date Deposited:	18 Mar 2023 07:03
Last Modified:	09 Feb 2024 03:54
URI:	http://research.manuscritpub.com/id/eprint/176

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