Infrared Spectroscopic Study of Binding Interaction of Metal Complexes with Mefenamic Acid (MFA)

Aims: The foremost aim of this study was to evaluate the 1:1 formed complex when mefenamic acid interacts with Cu2+, Zn2+, and EDTA4- metal at the physiological condition, which provides a better understanding of the pharmacological studies. This research provided information on the binding affinity of mefenamic acid with selective metals. It helps with preparative, structural, and reactivity studies for multiple drug designs in pharmaceutical fields.

Place and Duration of Study: Department of Pharmacy, Stamford University Bangladesh, Dhaka, Bangladesh & CARS ((Centre for Advanced Research in Sciences), University of Dhaka. The duration of this study is between September to December 2022.

Study Design: The Infrared spectra of Copper (Cu), Zinc (Zn), and Ethylenediaminetetraacetic Acid (EDTA) complex of Mefenamic Acid were investigated in the region between 4000 and 400 cm-1. These spectra were compared to standard peaks with specific functional groups. The binding interactions of the selected metal ions were demonstrated by significant variations in the intensities of the amino group of mefenamic acid after metal complexation.

Results: The interactions of the metal ions with the acid product have resulted in the alteration of the functional structure, characterized by a negligible reduction in the structure of mefenamic acid. The change in position of the characteristic bands, or the increase/ decrease in the number of bands and appearance of a new metal-atom bond, helps to confirm the formation of a complex.

Conclusion: It has been recently found that metal-based complexes decrease antiviral, antibacterial, and anticancer action. In order to construct actively functioning medications, it is vital to study the ability of physiologically active metal ions to interact with metalloproteinases like albumin, which transport and distribute these metal ions. The current research set a standard for repeatable mefenamic acid metal ion research.