Prospective Study of the Changes in Pharmacotherapy Cost of Adult Kidney Transplant Patients in Bulgaria

The purpose of the study is to analyze the changes in the ambulatory pharmacotherapy cost of kidney transplant patients in Bulgaria during the years 2006-2011 and the factors influencing it. It is a prospective cost study of changes in ambulatory pharmacotherapy cost. The cost of pharmacotherapy was calculated per patient per year and per month on average. In total, 21 therapeutic schemes were prescribed for 589 individuals per year on average. Most often, the prescribed therapeutic scheme was ciclosporin + mycophenolate, 38% to 39% of all cases during 2006 and 2011 respectively. Average cost of therapy differs in great interval and depends on age of the patients, place of transplantation, life with the graft, development of the citomegalovirus infection etc. Our study shows that the average monthly cost of pharmacotherapy decreases during 2006-2011, as a result of introduction of generic immune suppressors. All evaluated factors influence the statistically significant cost of pharmacotherapy.