Postinfection-post Vaccination Autoimmune Neural Long COVID-19: A Review

The normal physiological autoimmune condition might include auto-antibodies and auto-reactive immune cells in normal human subjects. On, post- sars-cov-2 infection and post-vaccination periods either the virus built in spike protein in case of post-infection. Or the peptide expressed from the spike protein sequence within the human COVID-19 mRNA vaccines have an auto-reacting epitopes within the human vaccinee cells. Both the virus spike protein and the vaccinee cells include either pan-sharing or mono-specific molecular mimicking epitopes that develop after repeated exposure to immune system cells causing autoimmune responses. The immune conversion state can lead to autoimmune tissue damage in the form of single or many organ abnormalities that express the patho-biologic characteristics of autoimmune long covid-19. The inclusion of long CoVID-19 on the list of autoimmune registry 2021 accords with this mechanistic interpretation of the long covid-19. Some workers feel that autoimmune long COVID-19 is a condition caused by autoantibodies. Other researchers believe that both auto-antibodies and auto-reacting immune cells are involved, while there is still some disagreement. This chapter presented a literature show case analysis of neural autoimmune long COVID-19 together with a suggestion to a laboratory animal model for Post-infection-Post-vaccination autoimmune long COVID-19 was suggested. Both of these disease entities are being over-lapping.