SCREENING OF LIPID PROFILE IN NON- OBESE HYPERTENSIVE SUBJECTS AT A TERTIARY CARE HOSPITAL IN BIHAR

Background: Obesity is a significant risk factor for metabolic syndrome in adults. Central fat distribution greatly alters the lipid profile and induces atherogenic dyslipidemia even in normoglycaemic, non-hypertensive subjects.

Aim and Objectives: Hence, the aim of the present study to assess lipid profile changes in non-obese hypertensive subjects. Obesity, hypertension and dyslipidemia are the three highly significant risk factor for the deranged lipid profile. Obesity can be defined as excess accumulation of body fat arising from a sustained or a periodic positive energy balance that when energy intake exceeds energy expenditure [1]. Indicators of overweight are useful in the diagnosis and management of obesity in both children and adults.

Materials and Methods: This study was conducted on newly diagnosed cases of essential hypertension attending medical outdoor of M.G.M. Medical College, Kisanganj. A complete clinical examination including laboratory investigation was done to exclude any systemic or other diseases which are likely to affect blood lipid levels directly or indirectly.

Results: The association between dyslipidaemia, obesity and hypertension is well established and all have been found to be major risk factor for the development of CAD, a leading cause of visits to physician and cause of death .

Conclusion: Our study was carry out to know the effect of obesity on lipid profile profile only in hypertensive and not in general population, and the study found some definite but paradoxical effects. These are that in obesity on a background of hypertension, the total and LDL cholesterol as also the HDL cholesterol are decreased, but on use other hand, the value of VLDL cholesterol and triglycerides are grossly and significantly increased. These finding have two major Clinical implications in that obese hypertensives will be more prone to metabolic syndrome and type 2 diabetes mellitus, and steps should be taken to prevent them accordingly and also apart from statins one should treat the obese hypertensives with fibrates, fat restriction and physical exercise also.