EFFECT OF OLIVE OIL EXTRACT ON LEAD INDUCED IN MICE, THE STUDY OF GLYCEMIA AND LIPIDEMIA IN NORMAL AND DIABETIC TREATED MICE

Lead is one of the environmental contaminant, which can threaten living organism in many ways. Mice treated with lead acetate found to exhibit significant production in hemoglobin content between normal and experimentally treated mice. The hematological values indicated a significant production in total white blood cells (WBC), red blood cells (RBC) count between normal and experimental. The level of high-density lipoprotein (HDL) in lead induced mice was found to be low with18.0 mgs/dl where as the control mice revealed an elevated high-density lipoprotein (HDL) level of 32.0 mgs/dl. Similarly the level of low-density lipoprotein (LDL), cholesterol was found be elevated than the control. Another biochemical parameter is the estimation of serum cholesterol which was found to be 90.0 mgs/dl with lead acetate induced mice and a remarkable decrease in serum cholesterol was established which exhibited 65.0mgs/dl. The results for serum triglycerides with lead induced mice showed 49.5 mgs/dl than compared to normal mice. Analysis of serum biomarkers such as lactate dehydrogenase (LDH) revealed an increased lactate dehydrogenase (LDH) level than the normal control mice. To study the kidney dysfunction the level of serum creatinine revealed an elevated level of 0.90 mgs/dl which is the remarkable effect leading to renal failure. The level of total bilirubin was found be eye in lead induced mice than the control treated mice. Studies pertaining to body weight absorbed during the periods of 15 days it was found be reduced in lead induced toxicity mice. To study of diabetic condition induced with streptozotocin (STZ) over a period of 15 days which exhibited significance rise in blood glucose concentration than the normal control mice. The study further extended the supplementation of olive oil in order to toxicity of lead acetate by olive oil revealed serum biomarker such as level of serum glutamate-pyruvate transminase (SGPT) in control showed 46.0 U/ML. Whereas in olive oil treated mice along with STZ induced mice revealed a moderate enzyme activity. Antipyretic study of olive oil by assessing the rectal temperature showed 40°C for control where as olive oil administered mice showed a rectal temperature of 40.5°C.