THE BIOCHEMICAL AND BEHAVIORAL RESPONSES OF FEMALE WISTAR RATS TO RESTRAINT STRESS

With the accelerated pace of life in todays’ world, pressures and tensions increase and the feeling of stress increases. In laboratory rodents, the stress induced by restraining the animal is inspired like any fear, by the fear of not being able to escape a tetanizing signal; thus; putting the organism in a heightened state of anxiety. The aim of our work is to induce restraint stress in 12 female Wistar rats at two pressure sessions per day (morning-after noon) over a 10-day period in order to quantify its effect on the behaviour of Wistar rats, on the one hand through the Open Field test and the Plus Maze test , on the other hand, on the variations of biochemical parameters such as glucose and lipid profile .Our results reveal the detrimental effect of stress on behaviour as well as a disruption of biochemical metabolism represented by a decrease in cholesterol levels and an increase in triglyceride and blood sugar levels .This also reinforces the importance of a healthy lifestyle in maintaining good health and therefore physical health.