Studies on Sulfadoxine Interaction with Bovine Serum Albumin Using Spectral and Molecular Modeling

The present study is focused on the binding interaction of sulfadoxine with bovine serum albumin under simulated physiological conditions using spectrofluorimetry. Various spectroscopic and other methods like Raman, CD, lifetime measurement, molecular modelling were also employed during the course of study. It was noticeable that sulfadoxine did quench the intrinsic fluorescence of BSA via static quenching process. The change in the secondary structure of BSA and binding mechanism was investigated with the spectral and docking studies.