Development in Oncological Hyperthermia

Hyperthermia was the very first oncotherapy in human medicine, but its applicability in modern
oncology was dubious. The discovery of electromagnetism gave new hope a century ago, however,
until up to now, it has been suffering from lack of wide acceptance. Oncological hyperthermia suffers
from multiple unsolved medical and technical problems. The accurate selection of malignant tissue
and its proper heating in depth are real challenges together with the control and repeatability of the
treatments. However, the center of the problems is not technical: the living system tries to keep its
homeostatic equilibrium and creates active feedback mechanisms to eliminate or at least correct the
constrain heating in depth. The proper reaction on the “gage of battle” has to involve the physiology,
handle it complexly together with bio-electromagnetism and update connected technology. The
solution has to be the integration of the natural bio-effects into the technological constrains, acting in
synergy with the physiological feedback mechanisms, and without forcing effects out of the
homeostatic control. The solution lies in strict selection and adequate action in nanoscopic range,
without exciting the robust transport-mechanisms to operate against the energy delivery to the tumor.
Together with the local optimization, the systemic effects have to be considered, because malignancy
is not a local disease. This concept needs interactions with the immune-system being effective on the
disseminated cell in far distance too. Our objective is to present a complex technical solution to this
complex problem.