Ahmadzadeh, Afrouz and Kessel, Line and Schmidt, Bo Simmendefeldt and Kolko, Miriam and Bach-Holm, Daniella (2024) Steroids and/or Non-Steroidal Anti-Inflammatory Drugs as Postoperative Treatment after Trabeculectomy—12-Month Results of a Randomized Controlled Trial. Journal of Clinical Medicine, 13 (3). p. 887. ISSN 2077-0383
![[thumbnail of jcm-13-00887.pdf]](http://research.manuscritpub.com/style/images/fileicons/text.png)
jcm-13-00887.pdf - Published Version
Download (1MB)
Abstract
This prospective randomized controlled trial aimed to compare the efficacy and safety of topical preservative-free diclofenac (DICLO) to dexamethasone (DEX) eyedrops, and their combination (DEX+DICLO) after trabeculectomy. Sixty-nine patients with medically uncontrolled glaucoma were randomized to receive topical postoperative treatment with DICLO (n = 23), DEX (n = 23), or a combination of DEX and DICLO (n = 23). The primary outcome was the intraocular pressure (IOP) 12 months postoperatively. Secondary outcomes included surgical success, failure, visual field, and visual acuity from baseline to 12 months postoperatively. IOP reached the lowest point one day after trabeculectomy. At 12 months, IOP was 10.0 mmHg (95% CI, 8.4–11.6 mmHg) for DICLO, 10.9 mmHg (95% CI, 9.4–12.3 mmHg) for DEX, and 11.2 mmHg (95% CI, 9.1–13.3 mmHg) for DEX+DICLO. There were no significant differences in IOP, surgical success, failure, visual field, or visual acuity between the DICLO, DEX, or DEX+DICLO groups. We found that topical diclofenac was not statistically different from topical dexamethasone in controlling IOP 12 months after trabeculectomy. Combining diclofenac and dexamethasone offered no added IOP control compared to dexamethasone alone
Item Type: | Article |
---|---|
Subjects: | Science Repository > Multidisciplinary |
Depositing User: | Managing Editor |
Date Deposited: | 05 Feb 2024 05:26 |
Last Modified: | 05 Feb 2024 05:26 |
URI: | http://research.manuscritpub.com/id/eprint/3946 |