Ocular Motor Cranial Nerve Palsies and Increased Risk of Primary Malignant Brain Tumors: South Korean National Health Insurance Data

Established risk factors for primary malignant brain tumors include hereditary syndromes, family history of brain tumors, head trauma, smoking, alcohol consumption, radiation exposure, electromagnetic wave exposure, infections, inflammation, and exposure to toxic substances. However, the impact of acquired ocular motor cranial nerve palsies on subsequent primary malignant brain tumors remains underexplored. Our research presents an exhaustive analysis of data from the Korea National Health Insurance Service from 2010 to 2017. Correlation between ocular motor cranial nerve palsies and emergence of primary malignant brain tumors within a Korean population was investigated. Our findings emphasize an amplified risk of primary malignant brain tumors in patients diagnosed with ocular motor cranial nerve palsies, particularly among women aged below 65.