Salem, Mo’men and Ayyad, Rezk and Sakr, Helmy and Gaafer, Ahmed (2022) Design and Synthesis of New Compounds Derived from Phenyl Hydrazine and Different Aldehydes as Anticancer Agents. International Journal of Organic Chemistry, 12 (01). pp. 28-39. ISSN 2161-4687
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Abstract
In this work we synthesized new derivatives from Phenyl Hydrazine and series of different Aldehydes (derivatives of benzylidenes). The synthesized compounds contain different aromatic Aldehydes which attached by Benzene ring via Hydrazine moiety in glacial acetic acid. These derivatives were characterized by TLC, melting points, Infrared Red, Proton Nuclear Magnetic Resonance, Carbon Thirteen Nuclear Magnetic Resonance and Mass Spectroscopy. Finally, these synthesized derivatives were tested for antiproliferative activity against multiple normal and cancerous cell lines, HepG2 (Liver cancer) and MCF-7 (Breast cancer) cell lines were used for cytotoxic assay.
Item Type: | Article |
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Subjects: | Science Repository > Chemical Science |
Depositing User: | Managing Editor |
Date Deposited: | 27 Feb 2023 05:00 |
Last Modified: | 24 Jun 2024 04:06 |
URI: | http://research.manuscritpub.com/id/eprint/684 |